《免疫学杂志》.2005年.第2期

基础医学

• Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3(CD223)
• IL-10 Diminishes CTLA-4 Expression on Islet-Resident T Cells and Sustains Their Activation Rather Than Tolerance
• Identification of Antigen-Capturing Cells as Basophils
• Phagocytosis-Induced Apoptosis in Macrophages Is Mediated by Up-Regulation and Activation of the Bcl-2 Homology Domain 3-Only Protein Bim
• Role of CD28 in Polyclonal and Specific T and B Cell Responses Required for Protection against Blood Stage Malaria
• Dendritic Cells and NK Cells Stimulate Bystander T Cell Activation in Response to TLR Agonists through Secretion of IFN- and IFN-1
• Dynamics of Dendritic Cell Phenotype and Interactions with CD4+ T Cells in Airway Inflammation and Tolerance
• The Reciprocal Interaction of NK Cells with Plasmacytoid or Myeloid Dendritic Cells Profoundly Affects Innate Resistance Functions
• Matrix Metalloproteinase-9 in Macrophages Induces Thymic Neovascularization following Thymocyte Apoptosis
• T Cells Undergo Rapid ON/OFF but Not ON/OFF/ON Cycling of Cytokine Production in Response to Antigen
• Peripheral "CD8 Tuning" Dynamically Modulates the Size and Responsiveness of an Antigen-Specific T Cell Pool In Vivo
• Human Autoantibodies Modulate the T Cell Epitope Repertoire but Fail to Unmask a Pathogenic Cryptic Epitope
• T Cells Undergo Rapid ON/OFF but Not ON/OFF/ON Cycling of Cytokine Production in Response to Antigen
• Induction of CD70 on Dendritic Cells through CD40 or TLR Stimulation Contributes to the Development of CD8+ T Cell Responses in the Absence
• Induction of CD70 on Dendritic Cells through CD40 or TLR Stimulation Contributes to the Development of CD8+ T Cell Responses in the Absence
• Vaccination with an Acidic Polymerase Epitope of Influenza Virus Elicits a Potent Antiviral T Cell Response but Delayed Clearance of an Infl
• Dysregulated B7-1 and B7-2 Expression on Nonobese Diabetic Mouse B Cells Is Associated with Increased T Cell Costimulation and the Developme
• Differential Activation of Anti-Erythrocyte and Anti-DNA Autoreactive B Lymphocytes by the Yaa Mutation
• Characterization of a B220+ Lymphoid Cell Subpopulation with Immune Modulatory Functions in Nasal-Associated Lymphoid Tissues
• Induction of Impaired Antitumor Immunity by Fusion of MHC Class II-Deficient Dendritic Cells with Tumor Cells
• Functional Heterogeneity of Memory CD4 T Cell Responses in Different Conditions of Antigen Exposure and Persistence
• Differential Role of Three Major New Zealand Black-Derived Loci Linked with Yaa-Induced Murine Lupus Nephritis
• Lipoprotein I, a TLR2/4 Ligand Modulates Th2-Driven Allergic Immune Responses
• IFN- Secreted during Infection Is Necessary but Not Sufficient for Negative Feedback Regulation of IFN- Signaling by Mycobacterium tuberculo
• TNF Receptor-Associated Factor 6 Is an Essential Mediator of CD40-Activated Proinflammatory
• Requirement for CD28 May Not Be Absolute for Collagen-Induced Arthritis: Study with HLA-DQ8 Transgenic Mice
• Changes in the Novel Orphan, C5a Receptor(C5L2), during Experimental Sepsis and Sepsis in Humans
• Quality of Recombinant Protein Determines the Amount of Autoreactivity Detected against the Tumor-Associated Epithelial Cell Adhesion Molecu
• Restricted IgA Repertoire in Both B-1 and B-2 Cell-Derived Gut Plasmablasts
• Generation of Murine CTL by a Hepatitis B Virus-Specific Peptide and Evaluation of the Adjuvant Effect of Heat Shock Protein Glycoprotein 96
• Tristetraprolin Down-Regulates IL-2 Gene Expression through AU-Rich Element-Mediated mRNA Decay
• Mast Cells, Basophils, and Eosinophils Acquire Constitutive IL-4 and IL-13 Transcripts during Lineage Differentiation That Are Sufficient fo
• Reductions in IB and Changes in NF-B Activity during B Lymphocyte Differentiation
• Bacterial Lipoprotein Induces Resistance to Gram-Negative Sepsis in TLR4-Deficient Mice via Enhanced Bacterial Clearance
• Abnormal Th1 Cell Differentiation and IFN- Production in T Lymphocytes from Motheaten Viable Mice Mutant for Src Homology 2 Domain-Containin
• The Rat Expresses Two Complement Factor C4 Proteins, but Only One Isotype Is Expressed in the Liver
• Innate Immunity in the Human Female Reproductive Tract: Antiviral Response of Uterine Epithelial Cells to the TLR3 Agonist Poly(I:C)
• p53 Potentiation of Tumor Cell Susceptibility to CTL Involves Fas and Mitochondrial Pathways
• The Expression of 11-Hydroxysteroid Dehydrogenase Type I by Lymphocytes Provides a Novel Means for Intracrine Regulation of Glucocorticoid A
• The Pathway of Antigen Uptake and Processing Dictates MHC Class II-Mediated B Cell Survival and Activation
• Human CD4+ Effector Memory T Cells Persisting in the Microenvironment of Lung Cancer Xenografts Are Activated by Local Delivery of IL-12 to
• Distinct Roles for IL-4 and IL-10 in Regulating T2 Immunity during Allergic Bronchopulmonary Mycosis
• The Notch Regulator Numb Links the Notch and TCR Signaling Pathways
• Proinflammatory Bacterial Peptidoglycan as a Cofactor for the Development of Central Nervous System Autoimmune Disease
• Fibroblast-Like Synoviocytes of Mesenchymal Origin Express Functional B Cell-Activating Factor of the TNF Family in Response to Proinflammat
• Resolution of a 16.8-Mb Autoimmunity-Regulating Rat Chromosome 4 Region into Multiple Encephalomyelitis Quantitative Trait Loci and Evidence
• The Notch Regulator Numb Links the Notch and TCR Signaling Pathways
• Viral Delivery of an Epitope from Haemophilus influenzae Induces Central Nervous System Autoimmune Disease by Molecular Mimicry
• Pharmacological Targeting of Anaphylatoxin Receptors during the Effector Phase of Allergic Asthma Suppresses Airway Hyperresponsiveness and
• Uncoupling of Anergy from Developmental Arrest in Anti-Insulin B Cells Supports the Development of Autoimmune Diabetes
• IN THIS ISSUE
• Autocrine Regulation of T Cell Motility by Calreticulin-Thrombospondin-1 Interaction
• Cutting Edge: Bcl-3 Up-Regulation by Signal 3 Cytokine(IL-12) Prolongs Survival of Antigen-Activated CD8 T Cells
• Heterogeneity of Expression of IgA Receptors by Human, Mouse, and Rat Eosinophils
• Cutting Edge: Role of STAT1, STAT3, and STAT5 in IFN- Responses in T Lymphocytes
• Cutting Edge: MHC Class II-Restricted Killing In Vivo during Viral Infection
• Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease
• Leukotrienes: Underappreciated Mediators of Innate Immune Responses
• Cutting Edge: Macrophage Inhibition by Cyclic AMP(cAMP): Differential Roles of Protein Kinase A and Exchange Protein Directly Activated by
• Importance of Cellular Microenvironment and Circulatory Dynamics in B Cell Immunotherapy
• Targeted Disruption of the 2B4 Gene in Mice Reveals an In Vivo Role of 2B4(CD244) in the Rejection of B16 Melanoma Cells
• IFN- Negatively Modulates Self-Renewal of Repopulating Human Hemopoietic Stem Cells
• CpG Oligodeoxynucleotides Enhance Neonatal Resistance to Listeria Infection
• A2A Adenosine Receptor Induction Inhibits IFN- Production in Murine CD4+ T Cells
• Transcriptional Profiling Reveals Complex Regulation of the Monocyte IL-1 System by IL-131
• Differential Activation of Anti-Erythrocyte and Anti-DNA Autoreactive B Lymphocytes by the Yaa Mutation
• TLR Ligands Can Activate Dendritic Cells to Provide a MyD88-Dependent Negative Signal for Th2 Cell Development
• Phospholipids Inhibit Lipopolysaccharide(LPS)-Induced Cell Activation: A Role for LPS-Binding Protein
• CXC Chemokine Ligand 16 Promotes Integrin-Mediated Adhesion of Liver-Infiltrating Lymphocytes to Cholangiocytes and Hepatocytes within the I
• The Double-Edged Sword of Activation-Induced Cytidine Deaminase
• Different MHC Class I Heavy Chains Compete with Each Other for Folding Independently of 2-Microglobulin and Peptide
• IFN- Suppresses STAT6 Phosphorylation by Inhibiting Its Recruitment to the IL-4 Receptor
• Phosphostim-Activated T Cells Kill Autologous Metastatic Renal Cell Carcinoma