《基因进展》.2005年.第5期

　

• Inactivation of TGF signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome
• machines for RNAi
• FGF8 initiates inner ear induction in chick and mouse
• A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
• Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nocic
• An initial blueprint for myogenic differentiation
• Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping
• Mammalian Polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1
• HFR1 is targeted by COP1 E3 ligase for post-translational proteolysis during phytochrome A signaling
• Saccharomyces cerevisiae imports the cytosolic pathway for Gln-tRNA synthesis into the mitochondrion
• Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms