《基因进展》.2005年.第10期

文章精

• Embryonic stem cell differentiation: emergence of a new era in biology and medicine
• PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
• Developmentally induced changes in transcriptional program alter spatial organization across chromosomes
• A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat
• Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencing
• BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II
• Zebrafish Hairy/Enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites
• p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes
• Vax genes ventralize the embryonic eye
• RNA-Guided RNA modification: functional organization of the archaeal H/ACA RNP