《血液学杂志》.2005年.第9期

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• A functional single-nucleotide polymorphism of the G-CSF receptor gene predisposes individuals to high-risk myelodysplastic syndrome
• Allogeneic hematopoietic cell transplantation for infants with acute lymphoblastic leukemia
• Quantitative PCR of bone marrow BCL2/IgH+ cells at diagnosis predicts treatment response and long-term outcome in follicular non-Hodgkin lym
• CD4+CD25+ regulatory T cells control induction of autoimmune hemolytic anemia
• Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene
• Increased peripheral platelet destruction and caspase-3–independent programmed cell death of bone marrow megakaryocytes in myelodysplastic p
• P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms
• Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-B–dependent manner
• A common Fanconi anemia mutation in black populations of sub-Saharan Africa
• Dendritic-cell activation by secretory phospholipase A2
• Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia
• Tumor necrosis factor-–dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability
• Transglutaminase-mediated oligomerization of the fibrin(ogen) C domains promotes integrin-dependent cell adhesion and signaling
• Uptake and presentation of hepatitis C virus–like particles by human dendritic cells
• Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells
• CpG stimulation of precursor B-lineage acute lymphoblastic leukemia induces a distinct change in costimulatory molecule expression and shift
• FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x(L)
• Sequential multiagent chemotherapy is not superior to high-dose cytarabine alone as postremission intensification therapy for acute myeloid
• Distinct types of primary cutaneous large B-cell lymphoma identified by gene expression profiling
• Hodgkin lymphoma therapy with interleukin-4 receptor–directed cytotoxin in an infiltrating animal model
• Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signal transduction
• Posttranslational modifications of p27kip1 determine its binding specificity to different cyclins and cyclin-dependent kinases in vivo
• The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage
• Farnesyltransferase inhibitor tipifarnib(R115777) preferentially inhibits in vitro autonomous erythropoiesis of polycythemia vera patient c
• Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor
• Proteomic analysis of mantle-cell lymphoma by protein microarray
• Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase C–dependent mechanisms
• Aberrant subcellular targeting of the G185R neutrophil elastase mutant associated with severe congenital neutropenia induces premature apopt
• Identification of a human B-cell/myeloid common progenitor by the absence of CXCR4
• Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytoge
• Jagged2 promotes the development of natural killer cells and the establishment of functional natural killer cell lines
• The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis
• Scl is required for dorsal aorta as well as blood formation in zebrafish embryos
• A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-1 in the development of myelofibrosis
• K-Ras is essential for normal fetal liver erythropoiesis
• A rich chemokine environment strongly enhances leukocyte migration and activities
• Single infusion of myeloid progenitors reduces death from Aspergillus fumigatus following chemotherapy-induced neutropenia
• Loss of Hspa9b in zebrafish recapitulates the ineffective hematopoiesis of the myelodysplastic syndrome
• TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expre
• Molecular modification of idiotypes from B-cell lymphomas for expression in mature dendritic cells as a strategy to induce tumor-reactive CD
• Reversal of long-term sepsis-induced immunosuppression by dendritic cells
• B-cell kinetics in humans: rapid turnover of peripheral blood memory cells
• B-cell kinetics in humans: rapid turnover of peripheral blood memory cells
• Fc receptor -chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses
• Ligands for natural killer cell–activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in a
• Activity and specificity of toxin-related mouse T cell ecto–ADP-ribosyltransferase ART2.2 depends on its association with lipid rafts
• Superantigen recognition by HLA class II on monocytes up-regulates toll-like receptor 4 and enhances proinflammatory responses to endotoxin
• The effect of first-line imatinib interim therapy on the outcome of allogeneic stem cell transplantation in adults with newly diagnosed Phil
• Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural kill
• A comprehensive genetic classification of adult acute lymphoblastic leukemia(ALL): analysis of the GIMEMA 0496 protocol
• Regional intravascular delivery of AAV-2-F.IX to skeletal muscle achieves long-term correction of hemophilia B in a large animal model