《实验药学杂志》.2005年.第1期

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• Of Interest in the JCB
• Inhibition of astroglial nuclear factor B reduces inflammation and improves functional recovery after spinal cord injury
• Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn
• Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis
• Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27Kip1 degradation
• Differential contributions of central and effector memory T cells to recall responses
• Plasmacytoid predendritic cells initiate psoriasis through interferon- production
• Many roads, one destination for T cell progenitors
• Dendritic cells star in Vancouver
• Thomas Rivers and the EAE model
• Progenitor of all trades
• Stressed out and asthmatic
• Phased by Notch
• Destructive T cells lured by lipids
• More mature and more promiscuous
• The timing of TCR expression critically influences T cell development and selection
• BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation
• Loss of C/EBP cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage
• Restricted MHC–peptide repertoire predisposes to autoimmunity
• v?3-dependent cross-presentation of matrix metalloproteinase–2 by melanoma cells gives rise to a new tumor antigen
• Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice
• Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
• A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision
• Contrasting models of promiscuous gene expression by thymic epithelium
• Hypoxia-induced neutrophil survival is mediated by HIF-1–dependent NF-B activity
• Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines
• Identification and characterization of an endogenous chemotactic ligand specific for FPRL2
• Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness
• Role of ?2-integrins for homing and neovascularization capacity of endothelial progenitor cells
• Discovering lymphocyte subsets
• MBL is good for the heart
• Surviving low oxygen
• Trouble-making NKT cells
• Heart-stopping antibodies
• Of Interest in the JCB
• Of Interest in the JCB
• A new look for 2005
• Mary Jo Turk, José A. Guevara-Pati?o, Gabrielle A. Rizzuto, Manuel E. Engelhorn, Shimon Sakaguchi, and Alan N. Houghton
• An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II–restricted T cells in the absence of CD4
• Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
• Conversion of CD4+ CD25– cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus
• Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk
• Positive selection of the peripheral B cell repertoire in gut-associated lymphoid tissues
• Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
• NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor ?1 production
• TACI and BAFF-R mediate isotype switching in B cells
• The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion
• Keeping a lid on eosinophil activation
• Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
• Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block
• Do developing B cells need antigen?
• Surviving low oxygen
• Trouble-making NKT cells
• Role of ?2-integrins for homing and neovascularization capacity of endothelial progenitor cells
• The Pim kinases control rapamycin-resistant T cell survival and activation
• TACI and BAFF-R mediate isotype switching in B cells
• Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
• Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block
• The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion
• Yellow fever 17D as a vaccine vector for microbial CTL epitopes : protection in a rodent malaria model
• A new look for 2005
• Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors
• Heart-stopping antibodies
• High frequency of antitumor T cells in the blood of melanoma patients before and after vaccination with tumor antigens
• Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines
• Identification and characterization of an endogenous chemotactic ligand specific for FPRL2
• Hypoxia-induced neutrophil survival is mediated by HIF-1–dependent NF-B activity
• Keeping a lid on eosinophil activation
• IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
• MBL is good for the heart
• Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
• Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness
• Conversion of CD4+ CD25– cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus
• Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen
• An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II–restricted T cells in the absence of CD4
• Do developing B cells need antigen?
• Discovering lymphocyte subsets
• Cotranslational endoplasmic reticulum assembly of FcRI controls the formation of functional IgE-binding receptors
• Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
• Mary Jo Turk, José A. Guevara-Pati?o, Gabrielle A. Rizzuto, Manuel E. Engelhorn, Shimon Sakaguchi, and Alan N. Houghton
• Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk
• NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor ?1 production
• NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145
• MBL is good for the heart
• Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues
• Positive selection of the peripheral B cell repertoire in gut-associated lymphoid tissues
• Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
• Reciprocal and dynamic control of CD8 T cell homin
• Positive selection of the peripheral B cell repert
• Phosphorylation-dependent translocation of sphingo
• Ro/SSA autoantibodies directly bind cardiomyocytes
• The Plasmodium circumsporozoite protein is proteol
• The Pim kinases control rapamycin-resistant T cell
• TACI and BAFF-R mediate isotype switching in B cel
• Synergy of IL-21 and IL-15 in regulating CD8+ T ce
• Yellow fever 17D as a vaccine vector for microbial
• Surviving low oxygen Neutrophils no longer surv
• Trouble-making NKT cells NKT cells aggravate ar
• Toll-like receptor 9 mediates innate immune activa
• Role of ?2-integrins for homing and neovasculariza
• Spred-1 negatively regulates allergen-induced airw
• Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen
• An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II–restricted T cells in the absence of CD4
• A new look for 2005
• Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors
• Do developing B cells need antigen?
• Discovering lymphocyte subsets
• Cotranslational endoplasmic reticulum assembly of FcRI controls the formation of functional IgE-binding receptors
• NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor ?1 production
• NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145
• MBL is good for the heart
• Mary Jo Turk, José A. Guevara-Pati?o
• Conversion of CD4+ CD25– cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus
• Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines
• Identification and characterization of an endogenous chemotactic ligand specific for FPRL2
• Hypoxia-induced neutrophil survival is mediated by HIF-1–dependent NF-B activity
• High frequency of antitumor T cells in the blood of melanoma patients before and after vaccination with tumor antigens
• Heart-stopping antibodies
• Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
• Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk
• Keeping a lid on eosinophil activation
• IL-23 drives a pathogenic T cell population that induces autoimmune inflammation