《毒物学科学杂志》.2005年.第1期

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• Mode of Mutagenic Action for the Biocide Bioban CS-1246 in Mouse Lymphoma Cells and Implications for Its In Vivo Mutagenic Potential
• In Vitro and in Vivo Analysis of the Thyroid Disrupting Activities of Phenolic and Phenol Compounds in Xenopus laevis
• European Commission, JRC–Joint Research Centre, Institute for Health & Consumer Protection, ECVAM–European Centre for the Validation of Alte
• Diagnosis: Toxic! – Trying to Apply Approaches of Clinical Diagnostics and Prevalence in Toxicology Considerations
• 2,3,7,8-Tetrachlorodibenzo-p-Dioxin(TCDD) Induces Organ- Specific Differential Gene Expression in Male Japanese Medaka(Oryzias latipes)
• Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan
• Differential Effects of Salen and Manganese-Salen Complex(EUK-8) on the Regulation of Cellular Cadmium Uptake and Toxicity
• Mechanisms of Exocrine Pancreatic Toxicity Induced by Oral Treatment with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Female Harlan Sprague-Dawle
• Department of Pathobiology
• Evaluation of Polycyclic Aromatic Hydrocarbons in the Activation of Early Growth Response-1 and Peroxisome Proliferator Activated Receptors
• Variability in Human Sensitivity to 1,3-Butadiene: Influence of Polymorphisms in the 5'-Flanking Region of the Microsomal Epoxide Hydrolase
• Genotoxic Effects on Spermatozoa of Carbaryl-Exposed Workers
• Derivation of a Human Equivalent Concentration for n-Butanol Using A Physiologically Based Pharmacokinetic Model for n-Butyl Acetate and Met
• Induction of Reactive Oxygen Species by Bisphenol A and Abrogation of Bisphenol A-Induced Cell Injury by DJ-1
• Differential Regulation of the Lung Endothelin System by Urban Particulate Matter and Ozone
• Nonparticulate Components of Diesel Exhaust Promote Constriction in Coronary Arteries from ApoE–/– Mice
• In Vitro Zonation and Toxicity in a Hepatocyte Bioreactor
• Exposure and Immunological Determinants in a Murine Model for Toluene Diisocyanate(TDI) Asthma
• Carcinogenic Activity of Cigarette Smoke Gas Phase and Its Modulation by Beta-Carotene and N-Acetylcysteine
• Seeking Optimal Design for Animal Bioassay Studies
• Manganese Potentiates In Vitro Production of Proinflammatory Cytokines and Nitric Oxide by Microglia Through a Nuclear Factor kappa B–Depend
• Differential Induction of Podocyte Heat Shock Proteins by Prolonged Single and Combination Toxic Metal Exposure
• Inflammatory and Cytotoxic Responses in Mouse Lungs Exposed to Purified Toxins from Building Isolated Penicillium brevicompactum Dierckx and
• Attenuation of Hyperoxic Lung Injury by the CYP1A Inducer –Naphthoflavone
• Metabonomic Identification of Two Distinct Phenotypes in Sprague-Dawley(Crl:CD(SD)) Rats
• Simultaneous Treatment with Citrate Prevents Nephropathy Induced by FYX-051, a Xanthine Oxidoreductase Inhibitor, in Rats
• Adverse Effects of Prenatal Exposure to Atrazine During a Critical Period of Mammary Gland Growth
• Comparison of Non-Human Primate and Human Whole Blood Tissue Gene Expression Profiles
• Relationship between Hepatic Gene Expression Profiles and Hepatotoxicity in Five Typical Hepatotoxicant-Administered Rats
• Probing the Control Elements of the CYP1A1 Switching Module in H4IIE Hepatoma Cells
• Photomutagenicity of Retinyl Palmitate by Ultraviolet A Irradiation in Mouse Lymphoma Cells
• Genotoxicity of Nicotine in Mini-Organ Cultures of Human Upper Aerodigestive Tract Epithelia
• Differential Expression of CYP1A, 2B, and 3A Genes in the F344 Rat following Exposure to a Polybrominated Diphenyl Ether Mixture or Individu
• Research Strategies for Safety Evaluation of Nanomaterials, Part II: Toxicological and Safety Evaluation of Nanomaterials, Current Challenge
• Neurochemical Effects of Chronic Dietary and Repeated High-Level Acute Exposure to Chlorpyrifos in Rats
• Exposure of Brown Norway Rats to Diesel Exhaust Particles Prior to Ovalbumin(OVA) Sensitization Elicits IgE Adjuvant Activity but Attenuate
• Glutathione Reductase Inhibition and Methylated Arsenic Distribution in Cd1 Mice Brain and Liver
• Dietary Exposure to Aroclor 1254 Alters Central and Peripheral Vasopressin Release in Response to Dehydration in the Rat
• Mitochondrial Dysfunction Occurs before Transport or Tight Junction Deficits in Biliary Epithelial Cells Exposed to Bile from Methylenediani
• Stachybotrys chartarum Alters Surfactant-Related Phospholipid Synthesis and CTP:Cholinephosphate Cytidylyltransferase Activity in Isolated F
• Involvement of Mrp2 in Hepatic and Intestinal Disposition of Dinitrophenyl-S-glutathione in Partially Hepatectomized Rats
• A Statistical Evaluation of Toxicity Study Designs for the Estimation of the Benchmark Dose in Continuous Endpoints
• Different Inhibitory Effects in the Early and Late Phase of Treatment with KAT-681, a Liver-Selective Thyromimetic, on Rat Hepatocarcinogene
• Tissue Manganese Concentrations in Lactating Rats and Their Offspring Following Combined in Utero and Lactation Exposure to Inhaled Manganes
• Pathophysiological Role of Poly(ADP-Ribose) Polymerase(PARP) Activation during Acetaminophen-Induced Liver Cell Necrosis in Mice
• Calcium Oxalate Monohydrate, a Metabolite of Ethylene Glycol, Is Toxic for Rat Renal Mitochondrial Function
• Structural Requirements for the Interaction of 91 Hydroxylated Polychlorinated Biphenyls with Estrogen and Thyroid Hormone Receptors
• Immune Mediators in a Murine Model for Occupational Asthma: Studies with Toluene Diisocyanate
• Acute Exposure to Molinate Alters Neuroendocrine Control of Ovulation in the Rat
• A Bio-Effect Directed Fractionation Study for Toxicological and Chemical Characterization of Organic Compounds in Bottom Sediment
• No Increase of Apoptosis in Regressing Mouse Liver after Withdrawal of Growth Stimuli or Food Restriction
• Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Kaohsiung 807, Taiwan, Republic of China
• PCB126 Induces Differential Changes in Androgen, Cortisol, and Aldosterone Biosynthesis in Human Adrenocortical H295R Cells
• Disruption of Thyroid Hormone Homeostasis at Weaning of Holtzman Rats by Lactational but Not In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo
• Selenium Compounds Prevent the Effects of Methylmercury on the in Vitro Phosphorylation of Cytoskeletal Proteins in Cerebral Cortex of Young
• cImpairment in Short-Term but Enhanced Long-Term Synaptic Potentiation and ERK Activation in Adult Hippocampal Area CA1 Following Developmen
• Precision-Cut Liver Slices as a New Model to Study Toxicity-Induced Hepatic Stellate Cell Activation in a Physiologic Milieu
• Effects of Sulfasalazine on Sperm Acrosome Reaction and Gene Expression in the Male Reproductive Organs of Rats
• Neonatal Toluene Exposure Alters Agonist and Antagonist Sensitivity and NR2B Subunit Expression of NMDA Receptors in Cultured Cerebellar Gra
• Inhibition of Voltage-Gated Potassium Currents by Gambierol in Mouse Taste Cells
• Tissue Distribution and Urinary Excretion of Inorganic Arsenic and Its Methylated Metabolites in Mice Following Acute Oral Administration of
• Cisplatin-Induced Apoptosis Is Enhanced by Hypoxia and by Inhibition of Mitochondria in Renal Collecting Duct Cells
• An Association of UDP-Glucuronosyltransferase 2B7 C802T(His268Tyr) Polymorphism with Bladder Cancer in Benzidine-Exposed Workers in China
• Incorporation of Therapeutic Interventions in Physiologically Based Pharmacokinetic Modeling of Human Clinical Case Reports of Accidental or
• Validation of Human Physiologically Based Pharmacokinetic Model for Vinyl Acetate Against Human Nasal Dosimetry Data
• Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity
• Dose-Dependent Modulation of the In Vitro Cytokine Production of Human Immune Competent Cells by Lead Salts
• Neurotoxicological and Statistical Analyses of a Mixture of Five Organophosphorus Pesticides Using a Ray Design
• 2,3,5-tris(Glutathion-S-yl)hydroquinone(TGHQ)-Mediated Apoptosis of Human Promyelocytic Leukemia Cells Is Preceded by Mitochondrial Cytochr
• Gene Expression in Normal Human Bronchial Epithelial(NHBE) Cells Following In Vitro Exposure to Cigarette Smoke Condensate
• Effects of Thimerosal on NGF Signal Transduction and Cell Death in Neuroblastoma Cells
• Coplanar PCB Congeners Increase Uterine Weight and Frontal Cortical Dopamine in the Developing Rat: Implications for Developmental Neurotoxi
• Atrazine and the Hypothalamo-Pituitary-Gonadal Axis in Sexually Maturing Precocial Birds: Studies in Male Japanese Quail
• Phenols, Quinolines, Indoles, Benzene, and 2-Cyclopenten-1-ones are Oviductal Toxicants in Cigarette Smoke
• Effects of Exogenous Sphinganine, Sphingosine, and Sphingosine-1-Phosphate on Relaxation and Contraction of Porcine Thoracic Aortic and Pulm
• Hepatic Gene Expression Changes throughout the Day in the Fischer Rat: Implications for Toxicogenomic Experiments
• The Refinement of Uncertainty/Safety Factors in Risk Assessment by the Incorporation of Data on Toxicokinetic Variability in Humans
• Thiamethoxam Induced Mouse Liver Tumors and Their Relevance to Humans
• Thiamethoxam Induced Mouse Liver Tumors and Their Relevance to Humans
• Genotoxicity of 4-Hydroxy-2-Nonenal in Human Colon Tumor Cells Is Associated with Cellular Levels of Glutathione and the Modulation of Gluta
• Differential Gene Expression in Human Peripheral Blood Mononuclear Cells Induced by Cigarette Smoke and Its Constituents
• Promotion of Thyroid Carcinogenesis by para-aminobenzoic Acid in Rats Initiated with N-bis(2-hydroxypropyl)nitrosamine
• Case Study: Weight of Evidence Evaluation of the Human Health Relevance of Thiamethoxam-Related Mouse Liver Tumors
• Immunotoxic Effects of Short-term Atrazine Exposure in Young Male C57BL/6 Mice
• The Threshold of Toxicological Concern Concept in Risk Assessment
• Effects of Organochlorine Insecticides on MAP Kinase Pathways in Human HaCaT Keratinocytes: Key Role of Reactive Oxygen Species
• Valproic Acid I: Time Course of Lipid Peroxidation Biomarkers, Liver Toxicity, and Valproic Acid Metabolite Levels in Rats
• Pronounced Synergistic Promotion of N-Bis(2-hydroxypropyl)Nitrosamine-Initiated Thyroid Tumorigenesis in Rats Treated with Excess Soybean an
• Effect of Cigarette Smoke on Autoimmunity in Murine and Human Systemic Lupus Erythematosus
• Phenobarbital and Phenytoin Increased Acetaminophen Hepatotoxicity Due to Inhibition of UDP-Glucuronosyltransferases in Cultured Human Hepat
• Modulation of Murine Host Response to Enteric Reovirus Infection by the Trichothecene Deoxynivalenol
• The Polysaccharide Antibody Response after Streptococcus pneumoniae Vaccination Is Differentially Enhanced or Suppressed by 3,4-Dichloroprop
• Induction of the Protective Antioxidant Response Element Pathway by 6-Hydroxydopamine In Vivo and In Vitro
• The Effects of Methylmercury on Mitochondrial Function and Reactive Oxygen Species Formation in Rat Striatal Synaptosomes Are Age-Dependent
• Effects of Methylmercury on Primary Brain Cells in Mono- and Co-culture
• Post-Intoxication Vaccination for Protection of Neurons against the Toxicity of Nerve Agents
• Transcriptional and Posttranscriptional Inhibition of Lysyl Oxidase Expression by Cigarette Smoke Condensate in Cultured Rat Fetal Lung Fibr
• Momentary Brain Concentration of Trichloroethylene Predicts the Effects on Rat Visual Function
• Workshop Proceedings: Managing Conflict of Interest in Science. A Little Consensus and A Lot of Controversy
• Composition, Toxicity, and Mutagenicity of Particulate and Semivolatile Emissions from Heavy-Duty Compressed Natural Gas-Powered Vehicles
• Temporal Integration of Nasal Irritation from Ammonia at Threshold and Supra-threshold Levels
• The Chemical Species of Aluminum Influences Its Paracellular Flux across and Uptake into Caco-2 Cells, a Model of Gastrointestinal Absorptio
• The Diverse Actions of Nicotine and Different Extracted Fractions from Tobacco Smoke against Hapten-Induced Colitis in Rats
• The Role of Protein Kinase C in Regulation of TCDD-Mediated CYP1A1 Gene Expression
• Estrogen-Induced Abnormal Accumulation of Fat Cells in the Rat Penis and Associated Loss of Fertility Depends upon Estrogen Exposure during
• Expression of Metallothoinein Isoform 3 Is Restricted at the Post-Transcriptional Level in Human Bladder Epithelial Cells
• A Commercial Mixture of the Brominated Flame Retardant Pentabrominated Diphenyl Ether(DE-71) Induces Respiratory Burst in Human Neutrophil
• Forced Uptake of Trivalent and Pentavalent Methylated and Inorganic Arsenic and Its Cyto-/genotoxicity in Fibroblasts and Hepatoma Cells
• Perinatal Lipopolysaccharide Exposure Downregulates Pregnane X Receptor and Cyp3a11 Expression in Fetal Mouse Liver
• Interactions of Contact Allergens with Dendritic Cells: Opportunities and Challenges for the Development of Novel Approaches to Hazard Asses
• Sustained Effect of Inhaled Diesel Exhaust Particles on T-Lymphocyte–Mediated Immune Responses Against Listeria monocytogenes
• Uptake and Disposition of Inhaled Methanol Vapor in Humans
• Developmental Toxicology Evaluations—Issues with Including Neurotoxicology and Immunotoxicology Assessments in Reproductive Toxicology Studi
• Prediction of 2-Year Carcinogenicity Study Results for Pharmaceutical Products: How Are We Doing
• Lipids versus Proteins as Major Targets of Pro-Oxidant, Direct-Acting Hemolytic Agents
• Aryl Hydrocarbon Receptors in the Frog Xenopus laevis: Two AhR1 Paralogs Exhibit Low Affinity for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin(TCDD)
• Effects of 2,4-D and DCP on the DHT-Induced Androgenic Action in Human Prostate Cancer Cells
• Regulatory Mechanisms Modulating the Expression of Cytochrome P450 1A1 Gene by Heavy Metals
• Paraquat Neurotoxicity is Distinct from that of MPTP and Rotenone
• Polybrominated Diphenyl Ether(PBDE) Effects in Rat Neuronal Cultures: 14C-PBDE Accumulation, Biological Effects, and Structure-Activity Rel
• Brief Postnatal PBDE Exposure Alters Learning and the Cholinergic Modulation of Attention in Rats
• Toxicogenomic Profile of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in the Murine Fetal Heart: Modulation of Cell Cycle and Extracellular Matrix Ge
• Late-Gestation Rat Myometrial Cells Express Multiple Isoforms of Phospholipase A2 That Mediate PCB 50-Induced Release of Arachidonic Acid wi
• Methoxychlor Directly Affects Ovarian Antral Follicle Growth and Atresia through Bcl-2- and Bax-Mediated Pathways
• Effect of Diesel Exhaust Particles on Allergic Reactions and Airway Responsiveness in Ovalbumin-Sensitized Brown Norway Rats
• Endothelin-1–Mediated Increase in Reactive Oxygen Species and NADPH Oxidase Activity in Hearts of Aryl Hydrocarbon Receptor(AhR) Null Mice
• Gene Expression Profiling of the PPAR-alpha Agonist Ciprofibrate in the Cynomolgus Monkey Liver
• Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on Murine Heart Development: Alteration in Fetal and Postnatal Cardiac Growth, and Postnatal C
• Metabolism and Hemoglobin Adduct Formation of Acrylamide in Humans
• Divergent Roles for Glutathione in Lindane-Induced Acute and Delayed-Onset Inhibition of Rat Myometrial Gap Junctions
• Cardiovascular Gene Expression Profiles of Dioxin Exposure in Zebrafish Embryos
• Inhibitory Effects of Vitamin A on TCDD-induced Cytochrome P-450 1A1 Enzyme Activity and Expression
• Enhancement by Estradiol 3-Benzoate in Thioacetamide-Induced Liver Cirrhosis of Rats
• A Novel Class of Cytochrome P450 Reductase Redox Cyclers: Cationic Manganoporphyrins
• Cytochrome P450 1A1 and 1B1 in Human Blood Lymphocytes Are Not Suitable as Biomarkers of Exposure to Dioxin-like Compounds: Polymorphisms an
• Development of a Physiologically Based Pharmacokinetic Model for Ethylene Glycol and Its Metabolite, Glycolic Acid, in Rats and Humans
• Enhancement of Cyanide-Induced Mitochondrial Dysfunction and Cortical Cell Necrosis by Uncoupling Protein-2
• Comparisons of Brain, Uterus, and Liver mRNA Expression for Cytochrome P450s, DNA Methyltransferase-1, and Catechol-O-Methyltransferase in P
• Altered Gene Expression During Rat Wolffian Duct Development following Di(n-Butyl) Phthalate Exposure
• Cytochrome P450 1B1 Is Required for 7,12-Dimethylbenz(a)-anthracene(DMBA) Induced Spleen Cell Immunotoxicity
• Issues in Risk Assessment for Developmental Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Compounds
• Sodium Methyldithiocarbamate Inhibits MAP Kinase Activation through Toll-like Receptor 4, Alters Cytokine Production by Mouse Peritoneal Mac
• Effects of Atrazine on CYP19 Gene Expression and Aromatase Activity in Testes and on Plasma Sex Steroid Concentrations of Male African Clawe
• Induction of Competing Apoptotic and Survival Signaling Pathways in the Macrophage by the Ribotoxic Trichothecene Deoxynivalenol
• Gene Expression Profiling of 17-Estradiol and Genistein Effects on Mouse Thymus
• Novel Progestogenic Activity of Environmental Endocrine Disruptors in the Upregulation of Calbindin-D9k in an Immature Mouse Model
• Modeling and Predicting Stress-Induced Immunosuppression in Mice Using Blood Parameters
• The Effect of a Brominated Flame Retardant, Tetrabromobisphenol-A, on Free Radical Formation in Human Neutrophil Granulocytes: The Involveme
• Signaling Modulation of Bile Salt-Induced Necrosis in Isolated Rat Hepatocytes
• Peroxisome Proliferator-Activated Receptors: Mediators of Phthalate Ester-Induced Effects in the Male Reproductive Tract?
• Compartmentalization of Redox Regulation of Cell Responses
• Aryl Hydrocarbon Receptor-Activating Polychlorinated Biphenyls and Their Hydroxylated Metabolites Induce Cell Proliferation in Contact-Inhib
• A Proposed Testing Framework for Developmental Immunotoxicology(DIT)
• Gingival Carcinogenicity in Female Harlan Sprague-Dawley Rats following Two-Year Oral Treatment with 2,3,7,8-Tetrachlorodibenzo-p-dioxin and
• Differential Expression of Mouse Hepatic Transporter Genes in Response to Acetaminophen and Carbon Tetrachloride
• PBPK Model for Radioactive Iodide and Perchlorate Kinetics and Perchlorate-Induced Inhibition of Iodide Uptake in Humans
• Gingival Carcinogenicity in Female Harlan Sprague-
• Differential Expression of Mouse Hepatic Transport
• Compartmentalization of Redox Regulation of Cell R
• Aryl Hydrocarbon Receptor-Activating Polychlorinat
• A Proposed Testing Framework for Developmental Imm
• The Effect of a Brominated Flame Retardant, Tetrab
• Signaling Modulation of Bile Salt-Induced Necrosis
• Peroxisome Proliferator-Activated Receptors: Media
• PBPK Model for Radioactive Iodide and Perchlorate
• Novel Progestogenic Activity of Environmental Endo
• Modeling and Predicting Stress-Induced Immunosuppr