《临床调查学报》.2005年.第8期

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• Cardiac and skeletal muscle disorders caused by mutations in the intracellular Ca2+ release channels
• Genetics of acquired long QT syndrome
• Long QT syndrome: from channels to cardiac arrhythmias
• Sodium channel mutations in epilepsy and other neurological disorders
• Muscle channelopathies and critical points in functional and genetic studies
• Inherited disorders of voltage-gated sodium channels
• HIV-1 fusion peptide targets the TCR and inhibits antigen-specific T cell activation
• Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients
• PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury
• Akt1/protein kinase B is critical for ischemic and VEGF-mediated angiogenesis
• Weaving Klotho into bile acid metabolism
• You are right too!
• Insulin infusion in acute illness
• Spring brings breezes, wheezes, and pollen oxidases
• A new direction for gene therapy: intrathymic T cell–specific lentiviral gene transfer
• Akt1 in the cardiovascular system: friend or foe
• ATP-sensitive potassium channelopathies: focus on insulin secretion
• Chloride channel diseases resulting from impaired transepithelial transport or vesicular function
• Autoantigen, innate immunity, and T cells cooperate to break B cell tolerance during bacterial infection
• PPAR regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1
• Induction of mucosal tolerance in Peyer‘s patch‘deficient, ligated small bowel loops
• In vivo correction of ZAP-70 immunodeficiency by intrathymic gene transfer
• Intensive insulin therapy protects the endothelium of critically ill patients
• Natural peptides selected by diabetogenic DQ8 and murine I-Ag7 molecules show common sequence specificity
• ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation
• The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice
• Saturated fat–rich diet enhances selective uptake of LDL cholesteryl esters in the arterial wall
• Human cardiac potassium channel DNA polymorphism modulates access to drug-binding site and causes drug resistance
• Impaired negative feedback suppression of bile acid synthesis in mice lacking Klotho
• Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice
• A mouse model of juvenile hemochromatosis
• The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages
• Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
• Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure
• Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
• The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
• The channelopathies: novel insights into molecular and genetic mechanisms of human disease
• Thyrotropin receptor–associated diseases: from adenomata to Graves disease
• Tom Cruise is dangerous and irresponsible
• Of mice and men: the iron age
• A molecule’s right to choose: how diabetogenic class II MHC products bind peptides