The globalized gene
http://www.100md.com
《加拿大医疗协会学报》
It was with some trepidation that I ventured into the world of The Global Genome: Biotechnology, Politics, and Culture, not so much because of the subject matter as the fact that the author, Eugene Thacker, is a professor of literature, communication and culture. Indeed, this book is part of a series from MIT Press that is "envisioned as a catalyst ... for diverse intellectual communities to explore common grounds of expertise ... in the evolving arena where art and science connect." Here, however, the intersection is that of biology with informatics.
Navigating as it does between the encoding and production of genomic information, its distribution in the form of international biocolonialism and biowarfare and the possibility of personally decoding and consuming through regenerative medicine, The Global Genome artfully achieves its ambitious aims.
This is not to say, however, that it does not wax rhetorical at times. In fact, resembling a cross between Alvin Toffler's Future Shock (1970) and Juan Enriquez's As the Future Catches You (2000), the book is at times arduous reading. We plough through Foucault's biopolitics, as well as Karl Marx and Georges Canguilhem, to name but a few philosophers summoned in Thacker's critical analysis of the triangulated relationship between DNA, databases and tissues in the redefinition of "life itself." Biology is seen as information — both material and immaterial, transformed into a technology itself: "In biopolitics, the body is a database, and informatics is the search engine." In particular, the Human Genome Project and population genomics come under heavy criticism as concerns the great patent debate and the medicalization of the notion of populations themselves — the population as the new territory of biocolonialism.
In spite of the overall richness of this book, the chapters on "Genomics and Databasing" and on "The Incorporate Bodies of Recombinant Capital" (that is to say, the correlations between medical and economic value systems) are particularly weak, and this for several reasons.
First, they are not contemporary, presuming as they do that DNA Sciences (a large-scale organized DNA sample bank) and its Gene Trust still exist, whereas they were abandoned in 2003. Likewise for the Tonga Gene Bank (Autogen), which in fact never began. Furthermore, the P3G (Public Population Project in Genomics) is actually an open-access resource for research tools and not a population database.
Second, these chapters are not wholly accurate in their understanding of population genomics and human diversity. Indeed, the author (like many others before him) demonizes Luca Cavalli-Sforza and the Human Genome Diversity Project (again, a project that never began). In fact, the recent results of the HapMap have served to validate Sforza's ideal of dissociating race from biology. Polymorphic differences reorganized in ancestral genomic blocks (haplotypes) show few "racial" differences. Race, however, cannot be discounted as a sociopolitical and cultural phenomenon with visible economic and health consequences.
Finally, bioinformatics and the biotech industry are reduced to "the continual transformation of biological value and medical value into economic value, a continual refashioning of the species being as at once biological and economic, as a form of 'biomaterial' labor." Likewise, biowarfare and biological security are depicted as political pretexts for power-grabbing through the normalization of states of emergency.
In contrast, the chapter on tissue engineering and regenerative medicine, while remaining critical, is more tempered and realistic. "[R]egenerative medicine is largely concerned with ensuring the body's protection from the dangers of certain contingencies that threaten its well-being." Thacker's critique is that, like the genecentric, reductionist approaches found in biotechnology, the concentration on the capacity of the body to "regrow" itself de-emphasizes environment and context such that the body is viewed in a cellular vacuum. According to the author, the concept of human labour — the real-time labour of the physical body — is replaced by the archival "labour" of cell cultures, databases and plasmid libraries. Ten years ago, the fear was of the genetization of society, while now it is of the technical redesign of life, the realization of the fictional X-Men.
This book constitutes a critical analysis of the integration of information and biotechnology. The challenge is to rethink the vitalist ideology of the life sciences. It offers a framework for a futuristic examination of current "advances," whether one agrees with the author's conclusions or not. The challenge offered by Thacker is to question whether the "complex" properties of "biological life itself" will lead us to innovation in both our thinking on the relation between the human and the nonhuman and in the fashioning of prospective policies.(Bartha Maria Knoppers)
Navigating as it does between the encoding and production of genomic information, its distribution in the form of international biocolonialism and biowarfare and the possibility of personally decoding and consuming through regenerative medicine, The Global Genome artfully achieves its ambitious aims.
This is not to say, however, that it does not wax rhetorical at times. In fact, resembling a cross between Alvin Toffler's Future Shock (1970) and Juan Enriquez's As the Future Catches You (2000), the book is at times arduous reading. We plough through Foucault's biopolitics, as well as Karl Marx and Georges Canguilhem, to name but a few philosophers summoned in Thacker's critical analysis of the triangulated relationship between DNA, databases and tissues in the redefinition of "life itself." Biology is seen as information — both material and immaterial, transformed into a technology itself: "In biopolitics, the body is a database, and informatics is the search engine." In particular, the Human Genome Project and population genomics come under heavy criticism as concerns the great patent debate and the medicalization of the notion of populations themselves — the population as the new territory of biocolonialism.
In spite of the overall richness of this book, the chapters on "Genomics and Databasing" and on "The Incorporate Bodies of Recombinant Capital" (that is to say, the correlations between medical and economic value systems) are particularly weak, and this for several reasons.
First, they are not contemporary, presuming as they do that DNA Sciences (a large-scale organized DNA sample bank) and its Gene Trust still exist, whereas they were abandoned in 2003. Likewise for the Tonga Gene Bank (Autogen), which in fact never began. Furthermore, the P3G (Public Population Project in Genomics) is actually an open-access resource for research tools and not a population database.
Second, these chapters are not wholly accurate in their understanding of population genomics and human diversity. Indeed, the author (like many others before him) demonizes Luca Cavalli-Sforza and the Human Genome Diversity Project (again, a project that never began). In fact, the recent results of the HapMap have served to validate Sforza's ideal of dissociating race from biology. Polymorphic differences reorganized in ancestral genomic blocks (haplotypes) show few "racial" differences. Race, however, cannot be discounted as a sociopolitical and cultural phenomenon with visible economic and health consequences.
Finally, bioinformatics and the biotech industry are reduced to "the continual transformation of biological value and medical value into economic value, a continual refashioning of the species being as at once biological and economic, as a form of 'biomaterial' labor." Likewise, biowarfare and biological security are depicted as political pretexts for power-grabbing through the normalization of states of emergency.
In contrast, the chapter on tissue engineering and regenerative medicine, while remaining critical, is more tempered and realistic. "[R]egenerative medicine is largely concerned with ensuring the body's protection from the dangers of certain contingencies that threaten its well-being." Thacker's critique is that, like the genecentric, reductionist approaches found in biotechnology, the concentration on the capacity of the body to "regrow" itself de-emphasizes environment and context such that the body is viewed in a cellular vacuum. According to the author, the concept of human labour — the real-time labour of the physical body — is replaced by the archival "labour" of cell cultures, databases and plasmid libraries. Ten years ago, the fear was of the genetization of society, while now it is of the technical redesign of life, the realization of the fictional X-Men.
This book constitutes a critical analysis of the integration of information and biotechnology. The challenge is to rethink the vitalist ideology of the life sciences. It offers a framework for a futuristic examination of current "advances," whether one agrees with the author's conclusions or not. The challenge offered by Thacker is to question whether the "complex" properties of "biological life itself" will lead us to innovation in both our thinking on the relation between the human and the nonhuman and in the fashioning of prospective policies.(Bartha Maria Knoppers)