Novel Vaccination Strategies
http://www.100md.com
《新英格兰医药杂志》
The world of vaccines traditionally has been considered to consist of a very limited number of tools for immunizing humans and animals. In recent years, however, advances in immunology and molecular genetics have permitted the development of innovative ways of inducing protective immunity. Centuries after Jenner's experiment with cowpox, vaccines have become extremely sophisticated weapons against infectious diseases. This book thoroughly reviews our understanding of the immunologic response to infectious diseases and the many recent advances in the development of vaccines. A number of experimental vaccines are discussed, and future strategies that may change the way in which infectious and other diseases will be prevented are also presented. Stefan Kaufmann, who is the founding director of the Max Planck Institute for Infection Biology in Berlin, has brought together a group of experts in various fields of vaccinology from Europe, the United States, and Australia for this challenging project.
Immunologists, developers of vaccines, clinical-trial specialists, and molecular biologists will find this book to be of interest. It begins with an engaging presentation about the challenges involved in the development of vaccines, including the search for serologic correlates of protection and the difficulty of developing vaccines for the many pathogens that are not associated with such serologic markers. Another section illustrates in detail the immunologic response to vaccines, beginning with the body's recognition of pathogens and ending with the mechanisms of immunologic memory. An outstanding section of the book is dedicated to adjuvants and vaccine vectors. An example is the use of the virus vector as a sort of Trojan horse, which can be engineered specifically for carrying the vaccine into the living organism.
I recommend this book to microbiologists, epidemiologists, and practitioners who administer vaccines. Indeed, reading the chapters that compare the traditional way of preparing and delivering vaccines with new techniques that are likely to be implemented in the near future is fascinating for all specialists. Of particular interest is the discussion of DNA vaccines, which may be used to prevent certain congenital or neonatal infections, such as infection with the herpes simplex virus or the human immunodeficiency virus (HIV). Also intriguing is the discussion of efforts to engineer types of living plants that would carry molecules capable of inducing an immune response. The possibility of producing large quantities of vaccine by this means would revolutionize preventive strategies, especially in developing countries. The book also covers the efforts to tailor vaccines to eradicate the world's major infectious killers, namely malaria, tuberculosis, and HIV. Advances in the development of vaccines against Helicobacter pylori and bioterror agents are also covered in this comprehensive book.
The final section on the safety and economic impact of vaccines is somewhat disappointing; this is a topic that merits a book in itself. Nonetheless, this section serves to remind us of the high priority that should be given to the safety of vaccines, of the need to provide accurate information to the public, and of the importance of vaccines in preventing disease and improving the health of the general population.
Alberto Eugenio Tozzi, M.D.
Ospedale Bambino Gesù
00165 Rome, Italy
alberto.tozzi@opbg.net(Edited by Stefan H.E. Kau)
Immunologists, developers of vaccines, clinical-trial specialists, and molecular biologists will find this book to be of interest. It begins with an engaging presentation about the challenges involved in the development of vaccines, including the search for serologic correlates of protection and the difficulty of developing vaccines for the many pathogens that are not associated with such serologic markers. Another section illustrates in detail the immunologic response to vaccines, beginning with the body's recognition of pathogens and ending with the mechanisms of immunologic memory. An outstanding section of the book is dedicated to adjuvants and vaccine vectors. An example is the use of the virus vector as a sort of Trojan horse, which can be engineered specifically for carrying the vaccine into the living organism.
I recommend this book to microbiologists, epidemiologists, and practitioners who administer vaccines. Indeed, reading the chapters that compare the traditional way of preparing and delivering vaccines with new techniques that are likely to be implemented in the near future is fascinating for all specialists. Of particular interest is the discussion of DNA vaccines, which may be used to prevent certain congenital or neonatal infections, such as infection with the herpes simplex virus or the human immunodeficiency virus (HIV). Also intriguing is the discussion of efforts to engineer types of living plants that would carry molecules capable of inducing an immune response. The possibility of producing large quantities of vaccine by this means would revolutionize preventive strategies, especially in developing countries. The book also covers the efforts to tailor vaccines to eradicate the world's major infectious killers, namely malaria, tuberculosis, and HIV. Advances in the development of vaccines against Helicobacter pylori and bioterror agents are also covered in this comprehensive book.
The final section on the safety and economic impact of vaccines is somewhat disappointing; this is a topic that merits a book in itself. Nonetheless, this section serves to remind us of the high priority that should be given to the safety of vaccines, of the need to provide accurate information to the public, and of the importance of vaccines in preventing disease and improving the health of the general population.
Alberto Eugenio Tozzi, M.D.
Ospedale Bambino Gesù
00165 Rome, Italy
alberto.tozzi@opbg.net(Edited by Stefan H.E. Kau)