Diabetes and Cardiovascular Disease: Integrating Science and Clinical Medicine
http://www.100md.com
《新英格兰医药杂志》
This extremely useful book describes the potential mechanisms underlying the macrovascular and microvascular complications of diabetes, the clinical manifestations of such abnormalities, and effective strategies for treatment. The information in its 500-plus pages is densely packed into two sections, one dealing with basic science (including 150 pages on vascular biology) and a larger section on clinical topics. In general, the chapters start with a brief introduction to a topic but rapidly move into very detailed descriptions of the subject at hand — for example, biochemical pathways. Each chapter succeeds in putting the basic-science aspect of the information into the context of the clinical setting. However, readers using this book as an introduction to diabetes may find it challenging and may benefit from reading a more general textbook before exploring the in-depth approach here.
Among patients with diabetes, 70 percent of deaths are attributed to cardiovascular disease. It is becoming increasingly clear that both metabolic and hemodynamic factors contribute to this risk. This book aims to introduce readers to a wide range of issues related to the disease, including epidemiology, economic implications, and treatment options and the evidence supporting them. Also detailed are the contribution of the endothelium to cardiovascular disease as a moderator of vascular tone, inflammation, and thrombosis; platelet function; impaired fibrinolysis and thrombosis; lipoprotein abnormalities; and links between nephropathy and atherosclerosis.
The most appealing feature of this book is that the proposed mechanisms underlying macrovascular and microvascular disease, which are briefly described in the chapters on clinical topics, are reviewed in depth in earlier chapters, thereby providing readers with a comprehensive summary in one book. The book will appeal both to basic scientists working in the fields of diabetes, insulin resistance, and obesity who wish to enhance their understanding of the clinical aspects of the disease and to clinicians seeking a clearer understanding of the underlying basic mechanisms.
Angela Shore, Ph.D.
Peninsula Medical School
Exeter EX2 5AX, United Kingdom
angela.shore@pms.ac.uk(Edited by Steven P. Marso)
Among patients with diabetes, 70 percent of deaths are attributed to cardiovascular disease. It is becoming increasingly clear that both metabolic and hemodynamic factors contribute to this risk. This book aims to introduce readers to a wide range of issues related to the disease, including epidemiology, economic implications, and treatment options and the evidence supporting them. Also detailed are the contribution of the endothelium to cardiovascular disease as a moderator of vascular tone, inflammation, and thrombosis; platelet function; impaired fibrinolysis and thrombosis; lipoprotein abnormalities; and links between nephropathy and atherosclerosis.
The most appealing feature of this book is that the proposed mechanisms underlying macrovascular and microvascular disease, which are briefly described in the chapters on clinical topics, are reviewed in depth in earlier chapters, thereby providing readers with a comprehensive summary in one book. The book will appeal both to basic scientists working in the fields of diabetes, insulin resistance, and obesity who wish to enhance their understanding of the clinical aspects of the disease and to clinicians seeking a clearer understanding of the underlying basic mechanisms.
Angela Shore, Ph.D.
Peninsula Medical School
Exeter EX2 5AX, United Kingdom
angela.shore@pms.ac.uk(Edited by Steven P. Marso)