Erectile dysfunction may be an early sign of heart disease, suggests new research
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《英国医生杂志》
Erectile dysfunction may not only have risk factors similar to those for cardiovascular disease, but it may also be an independent risk factor for such disease, new research presented this week suggests.
"If you can抰 get an erection, your heart may be heading in the wrong direction," said Dr Geoff Hackett, consultant in sexual dysfunction at Good Hope Hospital, Birmingham, at the annual congress of the European Society for Sexual Medicine in London.
A pilot study by Greek researchers evaluated the incidence of asymptomatic coronary artery disease in 26 men with erectile dysfunction and found that nearly a quarter (23%) had coronary artery disease confirmed by angiography. This is a substantially higher proportion, they said, than the 4% found in a previous study in the general population (European Heart Journal 2000;21:45-52). These findings suggest that patients with erectile dysfunction should be evaluated for cardiovascular disease, argued the researchers.
In another study of 162 patients, Italian researchers found that the prevalence of erectile dysfunction was high (66%) among those with chronic angina and multivessel disease and low (18%) among those who had had an acute myocardial infarction with only one vessel affected. Furthermore, men who had had an acute myocardial infarction and who also had erectile dysfunction were six times more likely to have multivessel disease than men who had normal erectile function.
"This suggests that erectile dysfunction may be a useful test to predict the extension of coronary artery disease in the case of acute coronary syndrome," said Dr Piero Montorsi of the University of Milan.
Results from another Italian study supported the role of smoking in erectile dysfunction. Of 860 middle aged men, 40% of men who had erectile dysfunction smoked heavily, compared with 4% in the control group.
"These results justify the need to raise awareness about the effect of tobacco on erectile function," said Dr Giuseppe Lombardi of the Careggi Hospital in Florence.
Dr Selim Cellek of University College London presented new data on a potential new treatment that could reverse erectile dysfunction induced by diabetes. "An estimated 30-40% of diabetic and aged patients with erectile dysfunction do not benefit from currently available drugs, including PDE-5 inhibitors. This is partly due to the accumulation of so called advanced glycation end products in the corpus cavernosum," Dr Cellek said. The researchers gave a new compound , ALT-711 (which breaks down advanced glycation end products) to diabetic rats, which significantly improved the animals?erectile function.(BMJ Raghav Chawla)
"If you can抰 get an erection, your heart may be heading in the wrong direction," said Dr Geoff Hackett, consultant in sexual dysfunction at Good Hope Hospital, Birmingham, at the annual congress of the European Society for Sexual Medicine in London.
A pilot study by Greek researchers evaluated the incidence of asymptomatic coronary artery disease in 26 men with erectile dysfunction and found that nearly a quarter (23%) had coronary artery disease confirmed by angiography. This is a substantially higher proportion, they said, than the 4% found in a previous study in the general population (European Heart Journal 2000;21:45-52). These findings suggest that patients with erectile dysfunction should be evaluated for cardiovascular disease, argued the researchers.
In another study of 162 patients, Italian researchers found that the prevalence of erectile dysfunction was high (66%) among those with chronic angina and multivessel disease and low (18%) among those who had had an acute myocardial infarction with only one vessel affected. Furthermore, men who had had an acute myocardial infarction and who also had erectile dysfunction were six times more likely to have multivessel disease than men who had normal erectile function.
"This suggests that erectile dysfunction may be a useful test to predict the extension of coronary artery disease in the case of acute coronary syndrome," said Dr Piero Montorsi of the University of Milan.
Results from another Italian study supported the role of smoking in erectile dysfunction. Of 860 middle aged men, 40% of men who had erectile dysfunction smoked heavily, compared with 4% in the control group.
"These results justify the need to raise awareness about the effect of tobacco on erectile function," said Dr Giuseppe Lombardi of the Careggi Hospital in Florence.
Dr Selim Cellek of University College London presented new data on a potential new treatment that could reverse erectile dysfunction induced by diabetes. "An estimated 30-40% of diabetic and aged patients with erectile dysfunction do not benefit from currently available drugs, including PDE-5 inhibitors. This is partly due to the accumulation of so called advanced glycation end products in the corpus cavernosum," Dr Cellek said. The researchers gave a new compound , ALT-711 (which breaks down advanced glycation end products) to diabetic rats, which significantly improved the animals?erectile function.(BMJ Raghav Chawla)