High risk groups are still not being vaccinated
http://www.100md.com
《英国医生杂志》
EDITOR—We agree with Mansoor and Wilson that hepatitis B vaccine has considerable efficacy even when the recommended schedule is not strictly adhered to. Two doses are possibly as effective as three doses, and the time interval between the second and the third doses may be unimportant.
Similarly, among infants born to HbeAg positive mothers, delayed administration of the vaccine or administration of vaccine alone without hepatitis B immunoglobulin seems to have considerable efficacy; however, whether this equals the efficacy of the recommended measures remains unclear. Our brief was to summarise the current standard recommendations and these remain unchanged despite the recent data.
As pointed out by Winstock, selective immunisation strategies aimed at high risk adolescents and adults do not work. We therefore believe that it may be wise to implement universal hepatitis B immunisation even in regions with low endemicity.
Similarly, among infants born to HbeAg positive mothers, delayed administration of the vaccine or administration of vaccine alone without hepatitis B immunoglobulin seems to have considerable efficacy; however, whether this equals the efficacy of the recommended measures remains unclear. Our brief was to summarise the current standard recommendations and these remain unchanged despite the recent data.
As pointed out by Winstock, selective immunisation strategies aimed at high risk adolescents and adults do not work. We therefore believe that it may be wise to implement universal hepatitis B immunisation even in regions with low endemicity.