APC proteolysis not overdone

http://www.100md.com 《细胞学杂志》

     "We've been led to believe that, since so many different antigens have to be made, APCs need a large, diverse set of activities," says Mellman. But dendritic cells (DCs) and B cells are no more endowed with lysosomal proteases than is the average fibroblast, based on the new results. Of the APCs tested, only macrophages were particularly protease packed.

    Reference:

    Delamarre, L., et al. 2005. Science. 307:1630–1634.(Smart antigen-presenting cells (APCs) us)

    http://www.100md.com/html/DirDu/2007/02/17/36/86/12.htm