CHANGES TO THE INSTRUCTIONS TO AUTHORS
http://www.100md.com
《核酸研究医学期刊》
1. Submission Instructions for Figures
With a view to reducing our publication times even further we now request that authors upload high resolution figures with their initial submissions. Full details, together with a list of acceptable file types, are available at http://www.oxfordjournals.org/nar/for_authors/msprep
2. Criteria for Consideration
The attention of authors is drawn to a number of significant changes aimed at clarifying and enhancing the standards expected for submitted manuscripts. For the full Criteria for Consideration, visit the NAR website at: http://www.oxfordjournals.org/nar/for_authors/criteria_scope.html. Please note the specific changes highlighted below.
Computational biology
Manuscripts will be considered only if they describe new algorithms that are a substantial improvement over current applications and have direct biological relevance. The performance of such algorithms must be compared with current methods and, unless special circumstances prevail, predictions must be experimentally verified. The sensitivity and selectivity of predictions must be indicated. Small improvements or modifications of existing algorithms will not be considered. Manuscripts must be written so as to be understandable to biologists. The extensive use of equations should be avoided in the main text and any heavy mathematics should be presented as supplementary material. All source code must be freely available upon request.
Molecular dynamics simulations
Manuscripts describing results from molecular dynamics simulations will be considered only if they provide valuable insights into biological questions related to nucleic acids. Theoretical results must be put into perspective with available structural and/or biological data, although it is not always essential for them to be accompanied by experimentation. However, theoretical interpretations or speculative ideas should be experimentally testable and, if not backed up by experimental results, should constitute only a small part of the manuscript. Constraints or limitations of the simulation method or theoretical approach used should be identified and discussed. Manuscripts must be written so as to be intelligible to as wide an audience as possible and should avoid jargon and undefined terms.
Protein-protein interactions
Manuscripts documenting protein-protein interactions, whether through computational or experimental means, will only be considered if one of the interacting proteins is of direct relevance to nucleic acid metabolism or gene regulation.
RNA biogenesis
Manuscripts dealing with promoters, enhancers, terminators, RNA polymerases, transcription factors and regulators, constitutive and alternative splicing, polyadenylation, editing, and RNA turnover should provide:
new and general insights into mechanism or control, with implications that extend beyond a particular gene, or
significant new information about the regulation of a gene whose products function in the synthesis, maturation, or degradation of RNA, or
new information about the structural biology of nucleic acid binding proteins that function in RNA biogenesis, particularly if these involve new motifs.
Findings should have demonstrated relevance to the native physiological or intracellular context in which the process occurs.
RNA function
Manuscripts dealing with the mechanisms of action, regulation, or assembly of ribosomes, snRNPs and other ribonucleoprotein particles should provide novel structural or functional insights, preferably with implications extending beyond a single gene or organism.
DNA metabolism
Manuscripts dealing with template features recognized during DNA replication, recombination or repair, as well as the enzymes and regulatory proteins that function in these processes should provide:
new and general insights into mechanism or control of DNA metabolism, or significant new information about proteins that act by directly contacting the template or by modulating chromatin structure, preferably with implications extending beyond a single organism.
new information about the structural biology of proteins or protein-DNA complexes relevant to chromosome transactions, particularly if these involve new motifs.
Findings should have demonstrated relevance to the native physiological or intracellular context in which the process occurs.
Nucleic acid delivery systems/Vectors
The journal considers manuscripts that describe novel viral or non-viral vector systems that are either based on entirely new principles or which demonstrate clearly and significantly improved effectiveness in a relevant biological system. These criteria apply also to delivery systems that lead to useful subcellular localization or mode of release of a cargo nucleic acid. Novel concepts of nucleic acid delivery and their underlying mechanisms are particularly encouraged. Derivatives of existing vector systems will not be considered.
With a view to reducing our publication times even further we now request that authors upload high resolution figures with their initial submissions. Full details, together with a list of acceptable file types, are available at http://www.oxfordjournals.org/nar/for_authors/msprep
2. Criteria for Consideration
The attention of authors is drawn to a number of significant changes aimed at clarifying and enhancing the standards expected for submitted manuscripts. For the full Criteria for Consideration, visit the NAR website at: http://www.oxfordjournals.org/nar/for_authors/criteria_scope.html. Please note the specific changes highlighted below.
Computational biology
Manuscripts will be considered only if they describe new algorithms that are a substantial improvement over current applications and have direct biological relevance. The performance of such algorithms must be compared with current methods and, unless special circumstances prevail, predictions must be experimentally verified. The sensitivity and selectivity of predictions must be indicated. Small improvements or modifications of existing algorithms will not be considered. Manuscripts must be written so as to be understandable to biologists. The extensive use of equations should be avoided in the main text and any heavy mathematics should be presented as supplementary material. All source code must be freely available upon request.
Molecular dynamics simulations
Manuscripts describing results from molecular dynamics simulations will be considered only if they provide valuable insights into biological questions related to nucleic acids. Theoretical results must be put into perspective with available structural and/or biological data, although it is not always essential for them to be accompanied by experimentation. However, theoretical interpretations or speculative ideas should be experimentally testable and, if not backed up by experimental results, should constitute only a small part of the manuscript. Constraints or limitations of the simulation method or theoretical approach used should be identified and discussed. Manuscripts must be written so as to be intelligible to as wide an audience as possible and should avoid jargon and undefined terms.
Protein-protein interactions
Manuscripts documenting protein-protein interactions, whether through computational or experimental means, will only be considered if one of the interacting proteins is of direct relevance to nucleic acid metabolism or gene regulation.
RNA biogenesis
Manuscripts dealing with promoters, enhancers, terminators, RNA polymerases, transcription factors and regulators, constitutive and alternative splicing, polyadenylation, editing, and RNA turnover should provide:
new and general insights into mechanism or control, with implications that extend beyond a particular gene, or
significant new information about the regulation of a gene whose products function in the synthesis, maturation, or degradation of RNA, or
new information about the structural biology of nucleic acid binding proteins that function in RNA biogenesis, particularly if these involve new motifs.
Findings should have demonstrated relevance to the native physiological or intracellular context in which the process occurs.
RNA function
Manuscripts dealing with the mechanisms of action, regulation, or assembly of ribosomes, snRNPs and other ribonucleoprotein particles should provide novel structural or functional insights, preferably with implications extending beyond a single gene or organism.
DNA metabolism
Manuscripts dealing with template features recognized during DNA replication, recombination or repair, as well as the enzymes and regulatory proteins that function in these processes should provide:
new and general insights into mechanism or control of DNA metabolism, or significant new information about proteins that act by directly contacting the template or by modulating chromatin structure, preferably with implications extending beyond a single organism.
new information about the structural biology of proteins or protein-DNA complexes relevant to chromosome transactions, particularly if these involve new motifs.
Findings should have demonstrated relevance to the native physiological or intracellular context in which the process occurs.
Nucleic acid delivery systems/Vectors
The journal considers manuscripts that describe novel viral or non-viral vector systems that are either based on entirely new principles or which demonstrate clearly and significantly improved effectiveness in a relevant biological system. These criteria apply also to delivery systems that lead to useful subcellular localization or mode of release of a cargo nucleic acid. Novel concepts of nucleic acid delivery and their underlying mechanisms are particularly encouraged. Derivatives of existing vector systems will not be considered.