How fish oils work
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《细胞学杂志》
-For years, epidemiologists and nutritionists have known that a diet high in the v-3 fatty acids found in fish oil correlates with a decreased risk of colon cancer. On page 915, Murray et al. explain why.
As colon carcinogenesis is accompanied by an increase in the expression of the lipid-dependent protein kinase C?II (PKC?II), the authors reasoned that -3 fatty acids might inhibit PKC?II signaling. Analysis of rat colonic epithelia and PKC?II transgenic mice demonstrated that -3 fatty acids block PKC?II activation and reduce the pro-carcinogenic effects of PKC?II in vitro and in vivo. PKC?II appears to repress the expression of transforming growth factor ? receptor II (TGF?RII), desensitizing cells to the growth-inhibiting effects of TGF?.
The results suggest that -3 fatty acids inhibit PKC?II, thus relieving the inhibition of TGF?RII expression. This renders colon epithelial cells sensitive to TGF?, and prevents or reverses the hyperproliferative state that leads to colon cancer. Dietary -3 fatty acids are also associated with preventing prostate and breast cancer and some neurological conditions, suggesting that PKC?II may be a promising target for multiple chemoprevention strategies.(3 (right), but not -6 (left), fatty acid)
As colon carcinogenesis is accompanied by an increase in the expression of the lipid-dependent protein kinase C?II (PKC?II), the authors reasoned that -3 fatty acids might inhibit PKC?II signaling. Analysis of rat colonic epithelia and PKC?II transgenic mice demonstrated that -3 fatty acids block PKC?II activation and reduce the pro-carcinogenic effects of PKC?II in vitro and in vivo. PKC?II appears to repress the expression of transforming growth factor ? receptor II (TGF?RII), desensitizing cells to the growth-inhibiting effects of TGF?.
The results suggest that -3 fatty acids inhibit PKC?II, thus relieving the inhibition of TGF?RII expression. This renders colon epithelial cells sensitive to TGF?, and prevents or reverses the hyperproliferative state that leads to colon cancer. Dietary -3 fatty acids are also associated with preventing prostate and breast cancer and some neurological conditions, suggesting that PKC?II may be a promising target for multiple chemoprevention strategies.(3 (right), but not -6 (left), fatty acid)