B族维生素在治疗慢性疼痛中的地位及作用机制讨论.doc
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B族维生素在治疗慢性疼痛中的地位及作用机制讨论
转载自丁香园网站
文中讨论了Vit B 在治疗Chronic pain(CP)方面的研究进展，非常好，并对治疗机制进行了推理。
目前这方面的研究不多，主要是因为治疗机理不明，很难建立合适的疼痛动物模型，最近动物模型有一定进展。
但临床上的应用早已开始，特别是在日本市场，复合Vit B(VBC)治疗慢性痛，已取得不殊的业绩。
最近，可以看到其它药物在治疗CP副作用报道越来越多，因此VBC的作用应被大家重视!
希望有兴趣者就此展开讨论!
==============================
Parker College Researchers Say Answer to Chronic Pain May Start With B-Vitamins
New Findings Reveal That This Treatment Could Be Highly Effective In Alleviating Pain Caused By Injury to the Nervous System
DALLAS, April 14 /PRNewswire/ -- Chronic pain affects some 86 million Americans a year and accounts for about $90 billion lost annually due to sick time, reduced productivity, and direct medical and other benefit costs. Many who suffer from chronic pain are told to learn to "live with it." Now new research indicates that relief may be found at the vitamin counter in your neighborhood grocery story.
Researchers in the Research Institute at Parker College of Chiropractic in Dallas, Texas, say they may have found an effective treatment for various painful conditions caused by injuries to the nervous system. Tests using B-vitamins, such as B1, B6, and B12, are showing significant results in blocking pain in laboratory rats.
Xuejun Song MD, PhD, Associate Professor and Associate Director of Basic Science Research, and Zhengbei Wang, MD, Postdoctoral Associate, both from the Parker Research Institute, are presenting their findings this week at the Experimental Biology meeting in San Diego (April 11-15, 2003) held by The American Physiological Society (APS) and the other five prestigious national research organizations. APS has identified the Parker team's study--one of thousands submitted from worldwide scientists--as one of the twelve that may hold potential interest for the public.
Dr. Song heads the research team, which conducted tests ranging 2-12 weeks to examine the short- and long-term effects of B-vitamins on rats that had been put through invasive operative procedures. The team's results found that both severity and duration of pain in these rats were significantly reduced depending on the dosage. "These studies strongly support and broaden the knowledge and clinical use of B-vitamins in aiding in treatment of chronic pain due to the nerve injury or spinal cord trauma and/or other injuries and diseases of the nervous systems," noted Song.
其中 Methyl B12的作用机理已有很多文章描述，它主要是通过修复受损伤的神经组织来达到治疗的目的：
1)容易高浓度地转运入神经细胞细胞器；(Inada et al. 1981)
2) 增强神经细胞内核酸和蛋白质的合成；(Nakazawa et al,1970)
3) 促进轴浆转运；( Takenaka,1982; Saito et al, 1981)
4) 促进髓鞘形成物质-磷脂的合成；(Yonezawa T. et al. 1981; Nakazawa T. et al, 1981)
5) 促进轴突的再生；(Onishi A. et al, 1979)
6) 加快突触传递的早期恢复；(Shibuya et. al, 1981)
7) 恢复被减少的神经传递物质。(Sasaki et al.,1992)
在日本有两个很知名的OTC产品，alinamin(武田)，nabolin(卫材)，主要成分都是B1、B2、B12(30mg/30mg/0.5mg)，他们的功效都是缓和关节痛、神经痛、肩痛、腰痛、眼疲劳等症状，作为止痛的辅助治疗药物，已被许多患者接受。
不知我们国内的医生对这种药物组合的评价是怎样的？
神经性疼痛
即使保守地估计 ......
B族维生素在治疗慢性疼痛中的地位及作用机制讨论
转载自丁香园网站
文中讨论了Vit B 在治疗Chronic pain(CP)方面的研究进展，非常好，并对治疗机制进行了推理。
目前这方面的研究不多，主要是因为治疗机理不明，很难建立合适的疼痛动物模型，最近动物模型有一定进展。
但临床上的应用早已开始，特别是在日本市场，复合Vit B(VBC)治疗慢性痛，已取得不殊的业绩。
最近，可以看到其它药物在治疗CP副作用报道越来越多，因此VBC的作用应被大家重视!
希望有兴趣者就此展开讨论!
==============================
Parker College Researchers Say Answer to Chronic Pain May Start With B-Vitamins
New Findings Reveal That This Treatment Could Be Highly Effective In Alleviating Pain Caused By Injury to the Nervous System
DALLAS, April 14 /PRNewswire/ -- Chronic pain affects some 86 million Americans a year and accounts for about $90 billion lost annually due to sick time, reduced productivity, and direct medical and other benefit costs. Many who suffer from chronic pain are told to learn to "live with it." Now new research indicates that relief may be found at the vitamin counter in your neighborhood grocery story.
Researchers in the Research Institute at Parker College of Chiropractic in Dallas, Texas, say they may have found an effective treatment for various painful conditions caused by injuries to the nervous system. Tests using B-vitamins, such as B1, B6, and B12, are showing significant results in blocking pain in laboratory rats.
Xuejun Song MD, PhD, Associate Professor and Associate Director of Basic Science Research, and Zhengbei Wang, MD, Postdoctoral Associate, both from the Parker Research Institute, are presenting their findings this week at the Experimental Biology meeting in San Diego (April 11-15, 2003) held by The American Physiological Society (APS) and the other five prestigious national research organizations. APS has identified the Parker team's study--one of thousands submitted from worldwide scientists--as one of the twelve that may hold potential interest for the public.
Dr. Song heads the research team, which conducted tests ranging 2-12 weeks to examine the short- and long-term effects of B-vitamins on rats that had been put through invasive operative procedures. The team's results found that both severity and duration of pain in these rats were significantly reduced depending on the dosage. "These studies strongly support and broaden the knowledge and clinical use of B-vitamins in aiding in treatment of chronic pain due to the nerve injury or spinal cord trauma and/or other injuries and diseases of the nervous systems," noted Song.
其中 Methyl B12的作用机理已有很多文章描述，它主要是通过修复受损伤的神经组织来达到治疗的目的：
1)容易高浓度地转运入神经细胞细胞器；(Inada et al. 1981)
2) 增强神经细胞内核酸和蛋白质的合成；(Nakazawa et al,1970)
3) 促进轴浆转运；( Takenaka,1982; Saito et al, 1981)
4) 促进髓鞘形成物质-磷脂的合成；(Yonezawa T. et al. 1981; Nakazawa T. et al, 1981)
5) 促进轴突的再生；(Onishi A. et al, 1979)
6) 加快突触传递的早期恢复；(Shibuya et. al, 1981)
7) 恢复被减少的神经传递物质。(Sasaki et al.,1992)
在日本有两个很知名的OTC产品，alinamin(武田)，nabolin(卫材)，主要成分都是B1、B2、B12(30mg/30mg/0.5mg)，他们的功效都是缓和关节痛、神经痛、肩痛、腰痛、眼疲劳等症状，作为止痛的辅助治疗药物，已被许多患者接受。
不知我们国内的医生对这种药物组合的评价是怎样的？
神经性疼痛
即使保守地估计 ......
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