29-人乳头瘤病毒检测对宫颈低度细胞学异常的寿命效应、成本和成本效益的影响：模拟研究.pdf
http://www.100md.com
| 第1页 |
参见附件(147kb)。
论著
Heal th Economics
Re sea rch Cent re,De partment of
Publ ic Heal th,Univers ity of
Oxford, Oxford
OX3 7LF,Rosa Legood,senior resea rcher
Alas tai r Gray,professor of hea lth
economics
Jane Wols tenholme,senior resea rcher
Cancer Scre ening
Evaluat ion Unit ,Inst itute of Cancer
Re sea rch, Sutton,Surre y SM2 5NG
Sue Moss ,a ssocia te di rector
Correspondence to:
R Legood
rosa. le good@
dphpc. ox. a c. uk
升高; 估计的数值比 CIN-3 级患者高。这可能与治疗的普通
方法和按照癌前病变的级别进行随诊有关。对所有病损均
进行治疗;但病损级别较低患者( CIN-1 和 CIN-2 ) 未受到和
高级别病损患者一样的系统和长期持久的随访。随访不足
是一个主要因素, 如文献中所显示的6 - 9。但是治疗宫颈上
皮内瘤样病变是有效的。在对 CIN-3 病损的早期研究中10
,据估计 28% ～ 39% 未接受治疗的病例将进展为浸润性宫颈
癌。我们的资料包括837 例 CIN-3 患者,年龄为 30 ～ 59 岁,如果按照以前的估计, 234 - 326 例将进展为浸润性宫颈癌,而不是观察到的3 例。因此治疗效果可能已接近 100% 。
关于作者 ( Contributors ) : IK contributed to the study conception and
design, analysis and interpretation of the data, and drafting the
manuscript . AA contributed to the study conception and design,interpret ation of the dat a, and drafting and revis ing the manuscript. EP
contributed to the analysis and interpretation of the data and drafting the
article. PN cont ributed to the study conception and des ign, interpretation
of the data, and drafting and revising the manuscript. He is guarantor.
资助( Funding) : This s tudy was partially financed from a grant from the
Finnish Cancer Organisation.
利益冲突( Competing interests ) : None declared.
伦理批准 ( Ethical approval ) : This study was approved by the ethical
committee of obstetrics and gynecology E8 of the Helsinki -Uusimaa
hospi tal district ( decision No 150 /E8 /03) .
( 祝洪谰 译)
参考文献
1 Inte rnat iona l Agency for R esearc h on Canc er. Ce rvical ca ncer sc reening. IARC
ha ndbooks of ca ncer prevent ion, vol 10 . Lyon: IAR C /WHO, 2005: 302.
2 Ant ti la A, L? ? r? E. In: Sankila R , Dé mare t E, Ha kama M, Lynge E,Sc houte n LJ , Pa rkin DM, for the Europea n Ne twor k of Cance r Re gist ries .
Eva luat ing a nd moni toring of screening programmes . Brus se ls /Luxembour g:
Eur opean Commis sion, Europe Against Cancer P rogr amme , 2000.
3 Mar tin-H irsch PL, Pa raskeva idis E, Ki tc hener H. Surgery for ce rvical
int raepi the lial ne opla s ia . Cochra ne Da ta ba se Syst Rev 1999; ( 3 ) : CD001318.
DOI: 10. 1002 /14651858. CD001318.
4 Soutter WP , de Barros Lopes A, F le tc her A, Mona ghan JM, Duncan ID,Para ske vaidis E, e t al . Inva sive cer vical ca ncer a fter conservat ive therapy for
cervic al intra epi thel ial neopla sia. La ncet 1997 ; 349: 978-80.
5 Teppo L, P ukkala E, Lehtonen M. Da ta qual i ty a nd qual ity cont rol of a
populat ion-ba se d ca ncer re gis t ry. Acta Oncol 1994; 33: 365-9.
6 Anders son- Ells tr m A, Se idal T, Gra nna s M, Ha gmar B. The pa p-smea r
his tory of wome n wi th invas ive cer vical squamous ca rcinoma . A c ase- cont rol
study from Swe de n. Acta Obstet Gynecol Sca nd 2000 ; 79: 221-6.
7 Sa sieni P D, Cuzik J , Lync h-F arme ry E , the Na tional Co-or dinat ing Network
for Ce rvical Sc ree ning Gr oup. Es t ima ting the efficac y of scre ening by audit ing
sme ars his tories of women wi th a nd wi thout c ervica l c ancer . Br J Ca ncer 1996;
73: 1001-5.
8 Balda uf J -J , Dreyfus s M, Ri t te r J , Meyer P , Phi lippe E. Scre ening his tories
of incide nce cases of c ervica l ca nc er and high gra de SIL: a compar ison. Acta ......
Heal th Economics
Re sea rch Cent re,De partment of
Publ ic Heal th,Univers ity of
Oxford, Oxford
OX3 7LF,Rosa Legood,senior resea rcher
Alas tai r Gray,professor of hea lth
economics
Jane Wols tenholme,senior resea rcher
Cancer Scre ening
Evaluat ion Unit ,Inst itute of Cancer
Re sea rch, Sutton,Surre y SM2 5NG
Sue Moss ,a ssocia te di rector
Correspondence to:
R Legood
rosa. le good@
dphpc. ox. a c. uk
升高; 估计的数值比 CIN-3 级患者高。这可能与治疗的普通
方法和按照癌前病变的级别进行随诊有关。对所有病损均
进行治疗;但病损级别较低患者( CIN-1 和 CIN-2 ) 未受到和
高级别病损患者一样的系统和长期持久的随访。随访不足
是一个主要因素, 如文献中所显示的6 - 9。但是治疗宫颈上
皮内瘤样病变是有效的。在对 CIN-3 病损的早期研究中10
,据估计 28% ～ 39% 未接受治疗的病例将进展为浸润性宫颈
癌。我们的资料包括837 例 CIN-3 患者,年龄为 30 ～ 59 岁,如果按照以前的估计, 234 - 326 例将进展为浸润性宫颈癌,而不是观察到的3 例。因此治疗效果可能已接近 100% 。
关于作者 ( Contributors ) : IK contributed to the study conception and
design, analysis and interpretation of the data, and drafting the
manuscript . AA contributed to the study conception and design,interpret ation of the dat a, and drafting and revis ing the manuscript. EP
contributed to the analysis and interpretation of the data and drafting the
article. PN cont ributed to the study conception and des ign, interpretation
of the data, and drafting and revising the manuscript. He is guarantor.
资助( Funding) : This s tudy was partially financed from a grant from the
Finnish Cancer Organisation.
利益冲突( Competing interests ) : None declared.
伦理批准 ( Ethical approval ) : This study was approved by the ethical
committee of obstetrics and gynecology E8 of the Helsinki -Uusimaa
hospi tal district ( decision No 150 /E8 /03) .
( 祝洪谰 译)
参考文献
1 Inte rnat iona l Agency for R esearc h on Canc er. Ce rvical ca ncer sc reening. IARC
ha ndbooks of ca ncer prevent ion, vol 10 . Lyon: IAR C /WHO, 2005: 302.
2 Ant ti la A, L? ? r? E. In: Sankila R , Dé mare t E, Ha kama M, Lynge E,Sc houte n LJ , Pa rkin DM, for the Europea n Ne twor k of Cance r Re gist ries .
Eva luat ing a nd moni toring of screening programmes . Brus se ls /Luxembour g:
Eur opean Commis sion, Europe Against Cancer P rogr amme , 2000.
3 Mar tin-H irsch PL, Pa raskeva idis E, Ki tc hener H. Surgery for ce rvical
int raepi the lial ne opla s ia . Cochra ne Da ta ba se Syst Rev 1999; ( 3 ) : CD001318.
DOI: 10. 1002 /14651858. CD001318.
4 Soutter WP , de Barros Lopes A, F le tc her A, Mona ghan JM, Duncan ID,Para ske vaidis E, e t al . Inva sive cer vical ca ncer a fter conservat ive therapy for
cervic al intra epi thel ial neopla sia. La ncet 1997 ; 349: 978-80.
5 Teppo L, P ukkala E, Lehtonen M. Da ta qual i ty a nd qual ity cont rol of a
populat ion-ba se d ca ncer re gis t ry. Acta Oncol 1994; 33: 365-9.
6 Anders son- Ells tr m A, Se idal T, Gra nna s M, Ha gmar B. The pa p-smea r
his tory of wome n wi th invas ive cer vical squamous ca rcinoma . A c ase- cont rol
study from Swe de n. Acta Obstet Gynecol Sca nd 2000 ; 79: 221-6.
7 Sa sieni P D, Cuzik J , Lync h-F arme ry E , the Na tional Co-or dinat ing Network
for Ce rvical Sc ree ning Gr oup. Es t ima ting the efficac y of scre ening by audit ing
sme ars his tories of women wi th a nd wi thout c ervica l c ancer . Br J Ca ncer 1996;
73: 1001-5.
8 Balda uf J -J , Dreyfus s M, Ri t te r J , Meyer P , Phi lippe E. Scre ening his tories
of incide nce cases of c ervica l ca nc er and high gra de SIL: a compar ison. Acta ......
您现在查看是摘要介绍页，详见PDF附件(147KB，5页)。