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    收稿日期:2006205202 修回日期:2007203206

    相关多药耐药基因产物在胃癌个体化治疗中的临床意义

    陶 春1

    ,罗明慧2

    ,季加孚3

    ,林 琳1

    ,郭 岩2

    ,张喜才4

    ,赵静华4

    ,强 欣1

    ,张 娟1

    (1.内蒙古民族大学医学院,内蒙古 通辽 028000 ; 2.呼伦贝尔市人民医院,内蒙古 海拉尔 021008 ;

    3.北京大学临床肿瘤学院,北京 100036 ; 4.内蒙古海拉尔农垦总医院,内蒙古 海拉尔 021000)

    中图分类号:R735. 2 ; R969. 3 文献标识码:A 文章编号:100622084(2007) 0720483203

    基金项目:内蒙古高等学校科学研究项目(NJ03170)

    摘要:为了解胃癌多药耐药基因及其产物表达对化疗效果的影响,应用现代信息技术,收集新近

    的有关文献进行综合分析,提出:联合检测 P2糖蛋白、 谷胱苷肽2S 2转移酶、 拓扑异构酶、 肺耐药相关蛋

    白等基因及基因产物,对化疗方案的制定及药物的选择意义重大,为开展个体化治疗提供依据。

    关键词:胃肿瘤;多药耐药基因产物;检测;个体化治疗

    Clinical Signif icance of Products Related to Multidrug Resistance Gene in Individualized Treatment for

    Stomach Cancer TAO Chun1

    ,LUO Ming2hui

    2

    , JI Jia2 fu3

    , et al . (1. Medical College , Inner Mongolia Universi2

    ty for Nationalities , Tongliao 028000 , China ; 2. People′ s Hospital in Hulunber City , Hailaer 021008 , China ; 3.

    Clinical Tumor College , Beijing University , Beijing 100036 , China ; 4. Hailaer General Hospital of Land Cultiva2

    tion , Hailaer 021000 , China)

    Abstract : In order to understand the effect of multidrug resistance genes and their gene products on chemo2

    therapy for the treatment of stomach cancer ,we collected and analyzed recent articles by using modern information

    technology as well as drew a conclution that detection of P2gp、 GST 2 π、 Topo Ⅱ、 LRP and their gene products in

    combination not only has an important significance in designing chems and drug selection ,but also provide basis for

    individulized treatment .

    Key words :Stomach cancer ; Product of multidrug resistance gene ; Detection ; Individualized treatment

    肿瘤细胞产生耐药性的原因是多方面的 ,其中以多药耐

    药(multi drug resistance ,MDR)最为常见。MDR 是指抗某种细

    胞毒药物的耐药细胞对许多结构上无关和作用机制上不同的

    其他细胞毒药物产生的交叉耐药。一般可以分为两种 ,一种

    为天然性耐药(initial resistance) ,即化疗前已有耐药;另一种为

    获得性耐药(acquired resistance ) ,即化疗过程中产生的耐药 ......